Saw palmetto is an herb that has been shown in clinical studies to have a role in maintaining a healthy prostate although not all studies have shown consistent benefits. Serenoa repens, sometimes referred to as sabal in Europe, grows naturally in the southeast United States, including Georgia, Mississippi, and particularly Florida. It is not the only herb that has an influence on the prostate gland. Several other herbs and plant compounds that are potentially useful including stinging nettle (Urtica diotica) leaf extract
Saw Palmetto appears that urinary symptoms resulting from mild-to-moderate prostate enlargement respond more readily to saw palmetto than symptoms due to severe enlargement. It often takes several weeks or months for the effects of saw palmetto and other herbs to be fully appreciated. These plants and extracts are effective and safe up to certain level dose on daily basis.
Prostate Power Rx for a healthier gland carefully formulated with high dose saw palmetto extract and important herbs and nutrients to provide optimal prostate health.
Saw Palmetto extract supplement guaranteed to supply 85-95% fatty acids and beneficial plant sterols, which are the herb’s key active ingredients. Note: In order for a saw palmetto product to be effective, it should supply a daily dose of 320 mg of 85 to 95% fatty acids. Some products that do not have these high potency fatty acid extracts may not be as effective.
Supplement Facts for Prosa-cut Uno
Saw Palmetto extract (- serenoa repens fruit) 540 mg.
Stinging Nettle leaf extract (Urtica diocia) 150.5 mg
Role in Prostate enlargement, benign prostatic hyperplasia (BPH)
The lipidosterolic extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a comparison of two dosage regimens.
Open study assessed the efficacy and tolerability of saw palmetto daily administered for 2 years. One hundred fifty-five men with clinically diagnosed BPH and complaints of prostatic symptoms were enrolled in the study. International Prostate Symptom Score and quality of life for those on saw palmetto improved significantly from baseline at each evaluation time point. Prostate size decreased. Sexual function remained stable during the first year of saw palmetto treatment and significantly improved during the second year. Prostate-specific antigen was not affected, and no changes in plasma hormone levels were observed. Nine patients reported 10 adverse events, none related to treatment with saw palmetto. Improvements in efficacy parameters began at 6 months and were maintained up to 24 months.
How does it work? Mechanism of action
Natural medicines have had far less research money devoted to them than they deserve. Saw palmetto is no exception, However, there have been enough studies to give us some clues. Some of the most likely mechanisms include the reduction in the amount of dihydrotestosterone (DHT) in prostate tissue, inhibition of the binding of DHT to androgen receptors in prostate cells, and the anti-estrogenic action in prostate tissue. Another possibility is the ability of compounds within saw palmetto to reduce the action of IGF-1 on prostate tissue. Insulin-like growth factor (IGF) action is important for prostate growth and development, and changes in the IGF system have been documented in BPH tissues.
Unlike Proscar finasteride, which has one active ingredient, saw palmetto has a number of different compounds within it. Thus, you can see why it would be complicated to evaluate all the possible interactions that these compounds have on a variety of tissues within our bodies. Furthermore, it is possible that a single compound within saw palmetto may not have much of an influence on its own although its combination with the other compounds would have a synergistic effect.
What about combining saw palmetto with other herbs?
Research shows when taken for 3 months, a combination of natural products (Saw palmetto, Stinging nettle i.e. Uritica dioica ) compared to placebo can significantly lessen nocturia and frequency and diminish overall symptoms of prostate enlargement.
Dosage and dose : The common dosage of saw palmetto is 540 mg of a 80-90% a day, or The dose can be split and taken twice daily.
Interactions with prescription medications :
• Limited research suggests that saw palmetto does not influence the ability of the liver to metabolize other drugs, for instance it does not alter the activity of cytochrome P450.
• As far as we know, the use of the herb does not interfere to any clinical degree with other medications but time will tell.
(Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland. Prostate. 2004.)
Furthermore, Stinging nettle root (Urtica dioica) is an herb with a long history of medicinal use, especially in Europe. For centuries, men with urinary tract problems have turned to this plant with an ominous name to relieve pelvic pain, urinary pain, burning, and other urinary symptoms. Stinging nettle soothes the urinary tract and also helps men with prostate problems. In addition to its anti-inflammatory properties, stinging nettle is a diuretic, and both of these characteristics make it a good candidate for prostate issues, including prostatitis and benign prostatic hyperplasia (BPH), which share some of the same urinary tract symptoms. While stinging nettle for prostatitis treatment may be used alone, it also works well when combined with other natural Supplements.
Stinging nettle is a Tier 2 supplement for prostatitis, meaning that there are significant clinical studies and research for using stinging nettle for prostatitis and similar prostate conditions. Research shows that this herb can help both men with chronic bacterial prostatitis and men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)
Some studies that involve using stinging nettle (along with other supplements) for bacterial and nonbacterial types of prostatitis
Researchers conducted a prospective, randomized study on men with chronic bacterial prostatitis to determine the therapeutic effect of saw palmetto, stinging nettle, with the antibiotic.
It is also useful to look at studies that involve using stinging nettle for BPH because sometimes prostatitis patients also experience lower urinary tract symptoms (LUTS) and may take the same medications as BPH patients. Laboratory studies have shown that stinging nettle is comparable to Proscar (finasteride), a drug commonly used to treat BPH, in inhibiting the growth of certain prostate cells. Scientists theorize that stinging nettle contains chemicals that have an impact on the hormones testosterone and estrogen, while another theory suggests the plant’s components work directly on prostate cells.
• Researchers in a European study asked 134 patients to take capsules containing extracts of stinging nettle and another prostate supplement called pygeum. After 28 days, symptoms of urine flow, residual urine, and nighttime urination were significantly reduced. Both pygeum and stinging nettle contain large amounts of beta-sitosterol, another prostate supplement.
Uses and Side Effects of Stinging Nettle : There have been various doses of stinging nettle used in clinical trials. Adults can take 240 to 500 mg a day of Uritica dioica root (or 2 to 4 grams of dried leaf) three times per day. It is best taken with some food and can generally be combined with other supplements.
Stinging nettle can cause occasional mild side effects such as stomach upset, rash, and fluid retention. Sweating and diarrhea are possible as well. Men who suspect prostate problems should check with their doctor and not self-treat with stinging nettle. Also, check with your doctor if you have bleeding disorders, kidney or bladder issues, low blood pressure, or diabetes. It may reduce effectiveness of warfarin or interfere with lithium. Elderly persons should use stinging nettle cautiously. Also talk to your doctor if you are taking nonsteroidal anti-inflammatory drugs (NSAIDS) because stinging nettle can enhance the anti-inflammatory effect of the drugs. While that may enhance pain relief, you need to check with your doctor to make sure it is safe.
References for Stinging Nettle for Prostatitis : Cai T et al. Serenoa repens associated with Urtica dioica and curcumin and quercitin extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomized study. Int J Antimicrob Agents 2009 Jun; 33(6): 549-53
Lopatkin N et al. Efficacy and safety of a combination of Sabal and Urtica extract in lower urinary tract symptoms—long-term follow-up of a placebo-controlled, double-blind, multicenter trial. Int Urol Nephrol 2007; 39(4): 1137-46.