*** Active Ingredient :
1-) N-Acetyl Cysteine600 mg. % DV * is a form of the essential amino acid cysteine, which is used to make glutathione, the body’s main antioxidant. By raising glutathione levels, your cells are protected from reactive oxygen species, and protected against DNA damage and cancer development.
The other main mechanism for NAC is in modulating inflammation both acutely from viruses, and also in chronic inflammatory conditions.
1-) NAC improves insulin sensitivity. Several studies have looked at the role of NAC in women with insulin resistance, and even compared with metformin. A reasonable dosage of 600 mg of NAC daily worked equally well to metformin, where both treatments resulted in lower fasting insulin, a significant decrease in weight, lower free testosterone and hirsutism and improved menstrual regularity. As you read more health benefits of NAC, you will understand why this supplement is likely a superior choice to metformin due to the other positive impacts (11, 12)
2-) Lowers testosterone levels and free androgen index Due to the effect on overall hormone balance, studies also show a significant drop in testosterone levels and also what is called the free androgen index which measures the ratio of testosterone to SHBG (sex hormone binding globulin) as an indicator of how much free testosterone is circulating (11,12). NAC offers an additional support to lower some of the more annoying symptoms of PCOS related to high androgens such as acne, hair loss and hirsutism.
3-) Improves menstrual regularity and frequency of ovulation NAC alone can improve menstrual and ovulation regularity as in the study comparing it to metformin above. Another study combined NAC with l-arginine supplements showing many cases of restored ovulatory cycles. Women with PCOS tend to have higher free radical levels which lowers nitric oxide. Nitric oxide has a positive role in the egg maturation process and ovulation (11, 13).
4-) Supports egg quality for fertility Through increasing intracellular glutathione levels, NAC can protect egg quality. In an additional study looking at egg quality for IVF cycles, and again in comparison to metformin, women treated with NAC for 6 weeks prior to their fertility treatment showed significantly better egg and embryo quality (14), and hence had higher fertility rates. This is worth considering, especially if you are trying to conceive over age 35 and need additional egg quality support.
5-) Lowers total cholesterol and LDL levels An added bonus to reducing insulin resistance and weight loss is a positive change in lipid levels. In women with PCOS, there was also noted a decrease in both total cholesterol and low-density lipoprotein levels (11).
6-) Works together with Clomid for improved fertility, better ovulation rate and higher progesterone levels When Clomid (clomiphene citrate) is combined with NAC for fertility, there is a significantly improved ovulation rate, compared to Clomid alone, along with better endometrial thickness and progesterone levels (15). It is important to note that a very common side-effect of clomid treatment is a thin endometrial lining, which is corrected by the addition of NAC. NAC will also boost ovulation rates in women who are ‘clomid-resistant’, meaning that clomid on its own will not induce ovulation. When combined with NAC, ovulation rates in one study went up from 1% to 49%, which is a very significant change (16).
Specifically for PCOS, NAC has an impact on insulin resistance, ovulation response and also hormone balance. It is certainly a supplement worth considering, in addition to work with your nutrition, exercise and stress management plan.
1-) Replenishing intracellular glutathione levels, which can become deficient with age and chronic illness.
2-) Protection against flu symptoms, meaning it reduces the severity and likelihood of having flu symptoms when exposed to the flu virus (1).
3-) Reduction of the frequency and duration of attacks in chronic obstructive pulmonary disease (COPD) and slowing the profession of pulmonary fibrosis.
4-) Blocks cancer development due to the reduction in oxidative stress and inflammation. NAC also induces cell death in multiple types of human cancer cells, slows tumor growth, protects the lungs from cigarette smoke-induced cancer, and shrinks colon polyps. In these and other mechanisms, NAC is considered a supplement for cancer chemoprevention (2,3,4,5,6).
5-) Inhibits growth of Helicobacter pylori infection in the stomach and reduces the production of inflammatory cytokines produced by this organism which can lead to gastritis and cancer (7,8).
6-) Reduction of symptom in obsessive-compulsive syndrome with daily use, including compulsive hair pulling, nail biting, skin picking, and even compulsive gambling (9,10).
Dosage and safety: The therapeutic dosage of NAC in almost all of the published studies is 600 mg 3x daily. If you are significantly overweight, a higher dose, closer to 1000 mg 3x daily may be required to see the benefits. NAC is considered a very safe supplement. The most common side-effect is stomach upset, usually being acid reflux of gastric irritation. This is usually resolved by taking the supplement with food rather than on an empty stomach, and not combining with coffee. There is some caution in people with asthma.
2. Chromium (Polynicotinate) 20 mcg. % DV 17%
Conclusion: Chromium picolinate decreased FBS and insulin levels and, thus, increased insulin sensitivity in clomiphene citrate-resistance PCOS women. These effects were comparable with metformin; however, metformin treatment was associated with decreased hyperandrogenism. Overall, chromium picolinate was better tolerated compared to metformin; nonetheless, the two study groups were not significantly different regarding ovulation and pregnancy rates.Registration ID in IRCT: IRCT201203139281N1
Chromium — specifically, trivalent chromium — is an essential trace element that’s used by some people as a supplement. Perhaps most importantly, chromium forms a compound in the body that seems to enhance the effects of insulin and lower glucose levels. However, it also had risks and its use is somewhat controversial.
Why do people take chromium?
Some studies have shown that chromium supplements may be helpful for people with type 2 diabetes and insulin resistance (prediabetes). There’s good evidence that chromium can lower glucose levels and improve insulin sensitivity, although not all studies have shown a benefit. It may be that chromium works better if someone is chromium deficient, which is usually only seen if a person has poor overall nutrition. Other studies have also found that chromium may help with polycystic ovary syndrome (PCOS), which is linked to insulin resistance.
Chromium supplements have also been studied for their effects on cholesterol, heart disease risk, psychological disorders, Parkinson’s disease, and other conditions. However, the study results have been contradictory or unclear.
Some people use chromium supplements to build muscle or trigger weight loss. Some chromium studies have shown these benefits, but others have not.
Chromium is an extremely important mineral if you have PCOS. It helps to encourage the formation of glucose tolerance factor (GTF) which is a substance released by the liver and required to make insulin more efficient. A deficiency of chromium can lead to insulin resistance, which is a key problem in the case of PCOS; too much insulin can be circulating but it is unable to control your blood sugar (glucose) levels.
Chromium is the most widely researched mineral used in the treatment of overweight. It helps to control cravings and reduces hunger. Chromium also helps to control fat and cholesterol in the blood. One study showed that people who took chromium over a ten-week period lost an average of 1.9kg (4.2lb) of fat while those on a placebo (sugar tablet) lost only 0.2kg (0.4lb)
If you are diabetic and on medication, you should speak to your doctor before taking chromium
3. VitaminE 12 IU. % DV 40%
Vitamin E helps with diabetes, hair loss, infertility, insulin resistance & irregular or absent periods. It is a powerful antioxident that plays a protective role in the body. As well as boosting your immune system, balancing blood sugar, improving hair and skin conditions, Vitamin E may also play a role in reducing the risk of heart disease (important for women with PCOS/IR). It also says to be sure that any multivitamin and mineral you take contains 30 mg of vitamin E. You can get it naturally through nuts, nut butters, vegetable oils (especially sunflower & wheat germ oil).Many studies have shown that a dose of between 400 – 800 i.u. depending upon the weight of the subject, of Vitamin E reduces insulin resistance as well as protecting cells against the damage caused by high blood sugar levels.
The Alpha Lipoic Acid Breakthrough, by Dr Burt Berksonpp 115-6
4. Riboflavin 1 mg % DV 59% (Vit B2) 5. Niacin 12 mg % DV 60% (Vit B3)
6. Pyridoxine HCL 1 mg % DV50% (Vit B6) 7. Pantothenic Acid 5 mg % DV 50% (Vit B5)
The B vitamins are very important in helping to correct the symptoms of PCOS. Vitamins B2, B3, B5 and B6 are particularly useful for controlling weight, and here’s why: Vitamin B2 helps to turn fat, sugar and protein into energy. B3 is a component of the glucose tolerance factor (GTF), which is released every time blood sugar rises, and vitamin B3 helps to keep the levels in balance. Vitamin B5 has been shown to help with weight loss because it helps to control fat metabolism. B6 is also important for maintaining hormone balance and, together with B2 and B3, is necessary for normal thyroid hormone production. Any deficiencies in these vitamins can affect thyroid function and consequently affect the metabolism.The B vitamins are also essential for the liver to convert your ‘old’ hormones into harmless substances which can then be excreted from the body.
8. ZnOxide 5.6 mg % DV 37%
Zinc is one of the key minerals that we need in our daily diets and it has a wide range of functions. Unfortunately, because our soil has been depleted by overfarming, there is very little natural zinc found in our food. Furthermore, processing and refining strip out what little might be remaining. So no matter how good your diet, you may not be getting anywhere near the levels of zinc that you need. There are two approaches to this: you can eat whole organic food, which has much more rigorous controls on farming methods, or you can add a zinc supplement to your diet. But why is it so important?Zinc is an important mineral for appetite control and a deficiency can cause a loss of taste and smell, creating a need for stronger-tasting foods, including those that are saltier, sugarier and/or spicier (in other words, often more fattening!). Zinc is also necessary for the correct action of many hormones, including insulin, so it is extremely important in balancing blood sugar. It also functions together with vitamins A and E in the manufacture of thyroid hormone.
9. Saw Palmetto 160 mg % DV * Saw Palmetto (Serenoa repens)
Saw palmetto is a herb that is traditionally considered in light of its success in treating prostate problems caused by an imbalance of hormones (including excess testosterone). It is a small palm tree found in North America and the berries of the tree are used in tinctures or capsule form.Research has shown that saw palmetto works as an anti-androgen, which can be very helpful given the high levels of testosterone in PCOS.I would suggest that you add saw palmetto to your treatment plan if you have excess hair growth, or have been told you have high levels of androgens. Otherwise, just take the agnuscastus, black cohosh and milk thistle.
10. Cinnamon Bark Powder 60 mg % DV *
11. Vitex 20 mg % DV *( Chastberry )
Agnuscastus (Vitex/chastetree berry) This is one of the most important herbs for PCOS because it helps to stimulate and normalise the function of the pituitary gland, which controls the release of LH (luteinising hormone).
Chaste tree, also known as vitex or chasteberry, may act as an anti-androgenic, lowering androgen levels, according to the University of Maryland Medical Center. Chaste tree may help regulate hormone imbalances, such as excess production of androgens or abnormal female-hormone production. Side effects can include itching, rash, headache, additional hair loss, rapid heartbeat, dry mouth and nausea. Do not take chaste tree without your doctor’s OK. Do not take it at all if you are pregnant.
Magnesium levels have been found to be low in people with diabetes and there is a strong link between magnesium deficiency and insulin resistance. It is, therefore, an important mineral to include if you are suffering from PCOS.Magnesium and Insulin Resistance
The theory behind magnesium treatments for PCOS is that magnesium levels are often low in people with both type 1 and type 2 diabetes, the more common type of diabetes that normally develops in middle age. Taking magnesium supplements can improve insulin sensitivity, according to Jerry Nadler, M.D. Decreased insulin sensitivity is a factor in the development of both type 2 diabetes and PCOS. Glucose in the bloodstream normally results in insulin release from the pancreas. Insulin helps cells absorb glucose. When cells become insulin resistant, they no longer respond normally to its release. It takes increasing amounts of insulin to get cells to respond to its signal to uptake glucose. Medications given to increase insulin sensitivity such as metformin, used to treat both PCOS and type 2 diabetes, increase magnesium levels in the liver.
*** Other Ingredients :
Stearic Acid, Dicalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, PharmaceuticalGlaze( Coating ).
Co-Enzyme Q10is a substance that your body produces in nearly every cell. It is important for breaking down carbohydrates and turning them into energy instead of being stored as fat. It also helps to balance your blood sugar.
Vitamin D, the sunshine vitamin, is now recognised as being so important in controlling blood sugar and improving insulin sensitivity. We also know that having low levels of vitamin D is associated with insulin resistance and obesity in women with PCOS.
Omega 3 fatty acidsThese essential fatty acids help your body become more sensitive to insulin and taken in supplement form have been found to reduce testosterone levels in women with PCOS and the greatest reduction is seen in those women who had high levels of Omega 6 fatty acids compared to Omega 3. That is why it is so important to get the correct balance of Omega 3 to Omega 6.
ProbioticsBeneficial bacteria, also known as probiotics, are important as they play a part In PCOS as they can help to control your weight. We know that there is a difference between the composition of the gut flora in normal weight and obese people.
Poor levels of beneficial bacteria can make your body store more calories and can actually make you become overweight by increasing your appetite and make you more insulin resistant.
We also know that probiotics can help reduce weight around the middle of the body (more common in PCOS weight gain.
Amino Acidsare the building blocks of the protein that you eat. Certain amino acids can be very helpful for PCOS as they can improve your insulin sensitivity and also can have an effect on weight loss e.g. n-acetyl cysteine, carnitine, tyrosine, arginine, glutamine, isoleucine, leucine and valine.
Furthermore, by adopting a healthier lifestyle you will be more likely to prevent Polycystic Ovary Syndrome (PCOS) which is discussed in detail in the rest of this ebook which you can read by clicking on Understanding Polycystic Ovary Syndrome (PCOS) ebook at The Natural Health Practice
Sometimes known as vitamin B-8, inosotol reduced insulin resistance and improved symptoms in women with PCOS in a study conducted by Virginia Commonwealth University. A 2007 Italian study conducted by the University of Perugia and reported by lead author S. Gerli also found that inosotol given with another B vitamin, folic acid, improved ovulatory function and also raised high-density lipoprotein levels, the protective “good” type of cholesterol. The study, which lasted 14 weeks, followed 92 women, half taking folic acid only as placebo and half taking a combination of inositol and folic acid. The inositol plus folic acid began to ovulate in 25 percent of cases, compared to 15 percent for the folic acid only group.
In the University of Perugia study, folic acid, also known as vitamin B-9 was given along with inositol. The combination of the two worked better than folic acid alone to improve PCOS symptoms. Folic acid has a protective effect against neural tube defects that occur in early pregnancy, so women with PCOS trying to get pregnant should take at least 400 mg of folic acid daily.Herbs are extremely useful in the treatment of PCOS. Making changes and adding supplements to your diet will help to control weight and balance blood sugar, while herbs go a step further, targeting any problems involving hormone balance.Herbs can also be very beneficial in encouraging the function of your liver, in order to make sure that it is metabolising the hormones efficiently and then eliminating them.
Black cohosh (Cimicifugaracemosa)This herb is so important for PCOS as it helps to reduce the hormone LH which is often too high. It is also beneficial for reducing anxiety and tension.
Milk Thistle (Silybummarianum)This is one of the key herbs for the liver, which acts as your waste disposal unit,, and it is therefore essential for the treatment of PCOS. It helps to protect your liver cells against damage and to promote the healing of damaged cells, so improving the general functioning of the liver and all its detoxifying properties.
*** Indications :1-) PCO : Poly-Cystic Ovarian Syndrome.2-) Symptomatic : Insulin Resistance, Ovarian Cysts, Anovulation, Hirsutism, Acne, Menstrual Disturbances, Obesity, and Ovulation.
*** Drug Interactions :None.*** Dose :Take One TabletTwice Daily or as directed by your healthcare practitioner.
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